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Dexaprine is advertised as a fat-burning appetite suppressant that claims to provide huge energy boosts to help weight loss attempts, but there has been controversy over some serious side effects.

Below we have reviewed Dexaprine against our review criteria to help consumers make an informed decision.

Dexaprine Review

Dexaprine Pros
  • Strong reviews from the bodybuilder community
  • Reformulated to exclude the dangerous ingredient DMAA
Dexaprine Cons
  • Associated with unpleasant and dangerous side effects
  • Ingredient quantities not disclosed

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Dexaprine Review

Dexaprine is a weight loss supplement that is claimed to be a powerful fat burner that helps to boost your energy and suppress your appetite. The product does however contain some controversial ingredients, some of which have been associated with severe side effects.

Claimed weight loss benefits

Dexaprine is claimed by the manufacturers to act as a fat burner, appetite suppressant, and metabolism booster.

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How Dexaprine Works

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Dexaprine is marketed as a powerful fat burner with appetite suppressant qualities. The large number of stimulant ingredients supposedly increases the metabolism in various ways, although particularly through the stimulation of norepinephrine. This potential increase in metabolism might help to burn more calories throughout the day, which contributes to weight loss. The energy boost from the stimulants may allow the user to stave off the sluggish feeling that strict diets can cause, and increase the alertness of the user. It also means that consumers who are participating in exercise can persevere with their efforts for longer without feeling tired. One active ingredient, Acacia Rigidula Extract, is thought to reduce the appetite of the user, aiding dieting efforts to reduce calorific intake.

Green Tea Extract

Green tea extract contains caffeine and high levels of antioxidants, including EGCG. This antioxidant is thought to both stimulate the metabolism in combination with caffeine, and to stimulate the hormone norepinephrine, which is thought to then suppress the appetite.

Citrus Aurantium

Citrus Aurantium (bitter orange) is thought to be a metabolic booster, with one of its main alkaloids, synephrine, targeting receptors in the body to stimulate the burning of fat in the body. This means that Dexaprine might affect fat cells especially, which could minimise the amount of muscle lost through dieting. Citrus aurantium has also been associated with appetite suppression in the past.

Acacia Rigidula Extract

Acacia Rigidula Extract (98%) is also present in the diet pill, and contains a large number of alkaloids that are said to promote fat burning in the body. There is also speculation that, as it is derived from a plant, this key ingredient may contain fibre that will add bulk in the stomach, reducing hunger for a short period of time.

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Key Dexaprine Ingredients


The original formula of Dexaprine contained 1, 3 dimethylamylamine, a stimulant that has been compared to amphetamines in its strength and potential danger. This active ingredient has been removed following the product being banned in several countries, including the UK, and the ingredient itself being banned for use in diet supplements in Canada, New Zealand and America. 1,3 dimethylamylamine works by increasing the thermogenic output of the body, and by stimulating the metabolism. Both of these should result in an increase in the number of calories burnt by the body daily, leading to weight loss over time. The new formula of the product contains a selection of stimulant ingredients.


The new formula of Dexaprine contains caffeine – a common stimulant that is thought to boost the metabolism and help with fat burning. The ingredient should also provide an energy boost, potentially improving athletic performance.

Green Tea Extract

Green tea extract is a key ingredient. This contains naturally occurring caffeine, but also contains a large amount of antioxidants, especially catechins, which have been linked to stimulating the production of increased levels of norepinephrine, which might also stimulate the metabolism for a few hours at a time.

Acacia Rigidula Extract

Acacia Rigidula Extract (98%) is listed amongst the primary ingredients, and is derived from an American plant called Blackbrush Acacia. This ingredient is thought to stimulate beta-receptors in the body to increase lipolysis and metabolic rate, as well as suppressing appetite. It is thought that the body becomes used to this adjustment after as little as 6 weeks, reducing its effect in the long term, but potentially making it efficient as a weight loss ingredient when initially used. More studies need to be conducted to determine to what extent Acacia Rigidula extract might aid weight loss.

Citrus Aurantium

Dexaprine also contains Citrus aurantium, which is also known as bitter orange extract or synephrine. This is another stimulant product, the safety of which is yet to be 100% verified in clinical trials. It has been associated with unpleasant side effects, and the importance of synephrine’s role in weight loss is yet to be conclusively proven.

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Clinical Studies

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The presence of clinical studies both verifies that the product is safe to use, and that the product will actually cause a change in weight loss. The information page on the official website suggests that all of the products sold by Iforce nutrition are subject to clinical trials as a part of the development process. However, the site neglects to provide any findings about any clinical trials conducted on the products, which raises some concerns about the claims made by the company. Without any information from clinical trials concerning Dexaprine, we must instead look at the next best set of information available, which is evidence from clinical trials concerning the individual ingredients of Dexaprine.


There is some clinical evidence to support the ingredient caffeine. Studies have shown that caffeine, as a stimulant, does boost the metabolism for a short period of time as well as increasing the thermogenic output of the body.

Green Tea

Green tea contains naturally occurring caffeine, which means that it might affect the metabolism. The other interesting part of green tea is it has a high level of antioxidants, particularly catechins such as EGCG. Whilst many antioxidants are useful to the body, one particular type of catechin, EGCG, is thought to be responsible for an increase in metabolism. Green tea has been found to increase thermogenesis in the body, which increases the metabolic rate of the user. A study carried out at the Department of Human Biology, Nutrition and Toxicology Research Institute at Maastricht University in the Netherlands discovered that drinking green tea can help a person significantly lose weight and maintain the lower weight once pounds have been lost.

Citrus Aurantium

Currently there is little evidence from clinical trials that this ingredient, also known as bitter orange extract or synephrine, impacts upon the body and the metabolism. Its safety as a dietary supplement has also not yet been established.

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Dexaprine Side Effects

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One death in the UK has been associated with Dexaprine. One woman died of caffeine toxicity following the consumption of 20 Dexaprine tablets in 2011. One of the key ingredients in the original formula, 1,3 dimethylamylamine (DMAA), has been linked with the death of London Marathon runner Claire Squires as well as four other deaths internationally and as a result it is becoming an increasingly restricted drug.

Users of Dexaprine have reported a number of side effects, although it is not always clear whether they were caused by the original banned formula or the new formula that is available in the UK. The original formula was banned in the Netherlands, Malta and the UK due to the fact that it was said to cause palpitations, chest pain, nausea, headache and cardiac arrest. Users have also reported that it causes anxiety, depression and mood swings several hours after taking the product.


The large amount of caffeine in the product also means that dehydration is a likely side effect if not enough water is consumed throughout the day. Increased urination, muscle cramps and sleep disturbances including insomnia are also potential side effects. Headaches, nausea, anxiety, and jitteriness might also be experienced, and some users will have an increased heart rate and blood pressure. User reviews suggest that some individuals have been finding the need to drink a large amount of water each day to stay hydrated.

Citrus Aurantium

Citrus aurantium, also known as synephrine, has been associated with raising blood pressure and heart rates in otherwise healthy adults, which raises concerns for the safety of long-term use of the ingredient. WebMD states that the relative safety of this product in comparison to ephedra has not been established, despite claims made by various manufacturers.

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How to Use

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The official recommendation from Iforce is to take one caplet per day, early in the morning. This supposedly results in the product working throughout the day to ensure that both the user’s appetite is suppressed and metabolism boosted. Iforce representatives do suggest that initially, for the first week or two of use, only half a caplet should be taken per day, as the product is strong and takes some getting used to. Many people seem to find that only half a caplet per day is strong enough, with some of these people finding that they experience negative side effects whilst taking a whole caplet per day, but no negative side effects with the lower dose.

Iforce representatives also suggest the possibility of taking a half caplet early in the morning and another half caplet in the early afternoon, if users find taking one whole caplet in the morning too strong. Users must however be aware that taking a dose in the afternoon may be more likely to cause sleep disturbances because of the stimulants in the product. All advice agrees that no more than one caplet should be taken per day, and users who have gone against this advice have reported a dramatic increase in side effects, especially an increase in resting heart rate, blood pressure and sleep disturbances.

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Who Makes It?

A company called Iforce Nutrition, which is based in California, America, manufactures Dexaprine. They supply to distributers internationally, focusing upon the body building community and dieters who wish to improve their physical fitness as well as losing weight. Their main products are categorised by them as sports supplements, clearly aimed towards physically active people.

The company claims on its official ‘about us’ page that when used effectively, their products “could increase lean muscle mass, extend endurance, reduce body fat, and accelerate recovery”. Their products are supposedly available with a “customizable individualized nutritional supplement program” to help customers achieve maximum results. This benefit is only mentioned on the official website, and not independent distributers, suggesting that this is only available when ordering direct from the Iforce nutrition website.

Iforce nutrition seems to be a generally reputable company that has a significant range of products, one of which is Dexaprine. The company has run into trouble in the past with certain ingredients featured in their diet pills, such as the use of 1,3 dimethylamylamine (DMAA) in the original formula of Dexaprine. The company has reformulated Dexaprine following several countries banning the sale of 1,3 dimethylamylamine (DMAA), and it is now back on sale in the UK, due to the ban being lifted.

The information page on the official website suggests that all of the products sold by Iforce nutrition are subject to clinical trials as a part of the development process. However, the site neglects to provide any findings about any clinical trials conducted on the products. The company has plenty of contact information available on its website, with several phone numbers for American customers, as well as several targeted email addresses for contacting sales or for general enquiries, and a postal address. There is also a quick contact form, which apparently sends an email direct to their inbox.

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Where to Buy Dexaprine


The original formula of Dexaprine is now difficult to source because of the bans on both Dexaprine and 1,3 dimethylamylamine (DMAA) internationally. The new formula is still available, and purchasable through several different bodybuilding websites and the official Iforce website.

You can purchase the new formula off the official Iforce website for £34.03 ($54.99); there is currently a sale where you can get 60 tablets for £24.75 ($39.99). The one bottle, due to only having to take either 1 or half a caplet, will last you between 2-4 months.

You can also purchase Dexaprine from eBay or bodybuilding websites. However, we would advise caution when purchasing from these places due to the risk of buying a counterfeit version of the product. If you do wish to try this diet pill, we would recommend you buy from the official website.

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Does Dexaprine Meet our Approved Criteria

Money-back-guarantee: No. There does not seem to be a money back guarantee.

One-off payment: Yes, purchase of this product appears to be a one-off payment.

Manufacturing Standard: There is no mention of any official manufacturing standards.

Accompanying Diet Plan: There is no mention of a diet plan with this product.

Ingredients and quantities disclosed: Ingredient quantities are not revealed.

Company contact details readily available: Contact details are provided on the official website.

Dexaprine does not meet our ‘Approved’ criteria as there is no money-back guarantee or diet plan and some information is lacking from the official website, including ingredient quantities and manufacturing standards.

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Overall Verdict

There is a large number of side effects associated with this weight loss supplement due to the stimulant ingredients. There is a lack of direct clinical research into Dexaprine, although there is some clinical support for a few of the key ingredients, notably caffeine and green tea extract. The original formula of Dexaprine contained 1,3 dimethylamylamine (DMAA) and so should not be consumed. The new product is sold by a fairly large supplements company that provides contact details, but a full ingredients list and manufacturing standards are not provided.

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