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Mangodrin is a supplement that supposedly uses African mango seed extract to support weight loss, apparently with no side effects. These claims made by the company have however not been backed by reliable scientific evidence.

Below we have reviewed Mangodrin against our review criteria to help consumers make an informed decision.

mangodrin review

Mangodrin Pros
  • Some of the ingredients have been clinically studied
  • Company offers a 30-day money-back guarantee
Mangodrin Cons
  • Stimulant content could cause side effects, some severe
  • Some important information lacking from the official website

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Mangodrin Review

Mangodrin consists of African mango seed extract and supposedly stimulants to aid weight loss. It is sold by TruDerma, a company that has varied customer reviews online. African mango seed extract has been suggested in a couple of studies to aid weight loss, something that the company uses as their selling point. However, by using this, TruDerma can mislead some customers into believing their supplement as a whole is clinically tested and has no side effects when in fact it contains more than just the mango seed. It contains a variety of stimulants used to boost the metabolism that can have unpleasant side effects.

Claimed weight loss benefits

Mangodrin claims to cause weight loss of up to 28 pounds in 10 weeks. It is supposedly designed to suppress appetite, boost metabolism and burn fat while promoting young and healthy skin.

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How Mangodrin Works

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Mangodrin is claimed to work by interfering with the hormones and enzymes in the body, altering appetite and absorption. The stimulants are said to kick start the metabolism and make the body feel energized. Appetite suppression means a lower calorific intake, increasing the rate at which fat is converted to energy. The higher the metabolism, the faster fat can be burned and used as energy, rather than being stored in the body. This supplement is based around the African Mango Extract, Irvingia Gabonensis IGOB131, derived from the mango seeds. Dr. Oz, the infamous celebrity ‘doctor’, was quoted saying it is a “miracle for your medicine cabinet.” The product contains a number of other ingredients, too.


Caffeine is a stimulant, which means it boosts energy levels and reduces tiredness. It is thought to achieve this by inhibiting adenosine, the hormone that makes the body feel sluggish and tired. It has been suggested that caffeine can increase metabolic processes by inducing thermogenic activity. It also stimulates the adrenal gland; increasing heart rate and blood pressure, which might make the body feel alert and focused. The production of adrenaline is also believed to induce lipolysis; the breakdown of larger fats into smaller fats making them easier to use for energy. 200mg of caffeine is present in the pills – equal to having around two cups of coffee. Caffeine effects can vary between users, depending on their tolerance level.

African Mango Seed Extract IGOB131 Proprietary extract

This is the ingredient that supposedlu holds weight loss properties. It is thought that African Mango seed can reduce appetite by lowering leptin levels. Leptin is a hormone which controls appetite and lower leptin is believed to mean that hunger is satisfied with lesser calorie intake. It is also claimed to increase the expression of Apiponectin, a hormone that regulates blood sugar levels, enhancing the effects of insulin. This might mean a higher uptake of glucose from the blood into cells and a higher rate of fat oxidation. Apiponectin has also been said to correlate with body fat percentage. When combined, leptin and Apiponectin are claimed to have complimentary effects with each other.

Green Tea Extract

The catechins in green tea have been said to have a small, positive effect on weight loss as it supposedly boosts metabolism and suppresses appetite. The polyphenols are believed to induce thermogenesis and fat oxidation, breaking down larger fats into smaller usable chunks. The most active compound in green tea, epigallocatechin gallate, is said to reduce appetite by inhibiting hunger related hormones. It also purportedly increases the production of CCK, an intestinal hormone involved in appetite control. Green tea contains caffeine so it also acts as a stimulant.


Picamilon is a Russian prescription drug used to treat illnesses such as depression, psychosis and migraines. It supposedly inhibits anxiety so might have been included to help with the side effects of Mangodrin.

Nettle leaf extract

Nettle leaf extract is a rich source of antioxidants and is used in traditional medicine to treat disorders involving the kidneys and bladder. There are no known weight loss properties so it is unclear why nettle leaf is included in Mangodrin.


This is a chemical compound often used in energy drinks. It is said to improve the absorption vitamin C and provide a high energy boost. There is no evidence to support weight loss apart from the implication of exercise associated with the increased energy. Glucuronolactone was once linked to brain tumours but has now been disassociated.

Inositol nicotinate

Inositol nicotinate is a product made naturally in the body. This ingredient is often found in skin care products and has no relation to weight loss. The metabolic breakdown of this ingredient supposedly reduces reddening of the skin caused by physical exercise or allergic reactions. This is used in Mangodrin to help adhere to their claims of promoting youthful skin.

Synephrine Caprylate

This ingredient is found naturally in bitter orange, a known stimulant. It contains synephrine which stimulants the body and is thought to encourage thermogenesis, therefore increasing calorie burning. They are also said to be able to suppress hunger due to their aromatic qualities, yet the clinical knowledge is limited as not much research has been carried out on humans. The safety of synephrine is controversial, showing particular risk when combined in caffeine; it might induce heart problems due to the increase in heart rate.

Yohimbe extract

Yohimbe is derived from a tree native to western Africa. Primarily used as an aphrodisiac, Yohimbe is an ingredient that can increase blood pressure when used in small amounts. Yohimbe bark is on the FDA list for dangerous supplements and can be fatal when taken in large amounts. It is used in bodybuilding supplements as it is believed to reduce body fat.

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Key Mangodrin Ingredients


Mangodrin contains African mango seed extract. This has been stated to improve leptin levels, a hormone that is thought to be involved in the control of appetite. It also apparently increases the secretion of Apidonectin, enhancing the effects of insulin by controlling glucose absorption.

The key ingredient is a proprietary extract, which means the actual quantity of mango seed is unknown and could be cut with other things to make it more profitable. It also contains stimulants including caffeine, synephrine, green tea and Glucuronolactone. These might boost metabolism while making the body feel pumped and alert.

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Clinical Studies

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TruDerma misleadingly state that the product as a whole has been clinically tested, which it has not. Clinical trials are essential for judging the efficacy and safety of a product. They are experiments based on a hypothesis that are conducted over a period of time to assess the results of a product. They are necessary for prescription drugs however they are not needed for supplements, which means untested products can be sold for public use. Even if the ingredients seem individually safe, they can have unpredictable and undesired effects when combined which is why it is important to test the whole product. For example, bitter orange is known to interact with caffeine.

As no clinical trials have been conducted on Mangodrin, here we will examine the trials behind the weight loss ingredients included in the product.

African Mango Seed Extract

One clinical trial is published as an advertisement for Mangodrin and is even printed on the product packaging.

The study consisted of 102 healthy and overweight subjects who were divided into two groups. One group were given a 150mg dose of IGOB131 30-60 minutes before breakfast, lunch and dinner. The other group were given a placebo. The results were observed at 4, 8 and 10 weeks of the study. There were significant improvements in body fat, waist circumference and Apidonectin and leptin levels. The researchers concluded that African mango seed extract IGOB131 “may prove to be a useful tool in dealing with the emerging global epidemics of obesity.”

The extract number is important to note because Mangodrin incorporates the same form of extract that was used in the trial which is something companies often mislead their customers about, using cheaper, ineffective alternatives. This study suggested that African mango seed extract is effective for weight loss. However, Mangodrin uses 150mg proprietary extract, which means the exact quantity of mango extract is not disclosed and is highly unlikely to be 150mg. The quantity of ingredient used can alter its effects.


Caffeine has several proven effects but weight loss is still a debatable issue. From many studies it seems caffeine does improve energy levels and metabolism on a short-term basis but with regards to weight loss, the evidence is still inconclusive. A study used four trials to test the impacts of caffeine and coffee on metabolic rate. The trials involved both normal-weight and obese subjects that consumed either caffeine or a placebo. It was found that caffeine could increase the metabolic rate during the three hours after consumption. This study indicates a short term increase in metabolism.


One review paper discusses a selection of studies on bitter orange. 15 overweight subjects were tested, with bitter orange extract consisting of 54mg dosage of p-synephrine for 6 hours. The effects were cardiovascular, with an increase in heart rate and blood pressure. The researchers repeated this trial 16 times between 1999 and 2011, changing the variables each time. For example they would change the dosage of p-synephrine, may add caffeine and change the amount of subjects. Yet the trend that is apparent regardless to dosages was time.

The subjects that were tested for 6 hours or less showed increases in blood pressure, heart rate and calorie use. However, the subjects who were tested for longer (up to 56 days) did not show any adverse effects. The trials where the bitter orange extract was combined with caffeine showed an increase in metabolic rate and calorie use. In animal testing, 95% did not show any effects of consuming bitter orange alone but when combined with caffeine they shown increases in cardiovascular activity such as blood pressure and heart rate. This shows that the combination of caffeine with synephrine boosts its effect yet these results cannot be assumed for humans without further testing. Weight loss was prevalent in human subjects when tested with a caffeine combination but the researchers couldn’t distinguish “whether the weight loss and increase in basal metabolic rate were due to the caffeine, the bitter orange extract, exercise, caloric restriction or a combination thereof.”

The researchers of this trial also concluded that synephrine was effective in raising metabolism for up to 12 weeks of consumption only, therefore being a short term solution. There was no evidence found for synephrine acting as an appetite suppressor.

Green Tea Extract

Green Tea extract is known to have many beneficial effects on the body but not may clinical trials have been done investigating the weight loss properties of green tea. Researchers believe the catechins within green tea are what may cause weight loss but the results have been so varied there is not a conclusive result. A trial was carried out on 10 healthy men who were given green tea, caffeine and a placebo to examine the relationship with energy-expenditure and fat oxidation. Those who were given green tea were found to have an increase in 24 hour energy-expenditure with a decrease in respiratory quotient and no change in urinary nitrogen. This proved that green tea has thermogenic properties and promotes fat oxidation in the body.

A different clinical trial was performed in a hospital, for 12 weeks, with 60 obese patients. All patients received the same three meals a day but only half of the group were given green tea. The half who received the tea, were found to lose more weight (an average of 24 pounds) in comparison to the 30 who didn’t receive green tea. Researchers found that this was due to the increase in fat oxidation and energy expenditure in those who drank green tea. However another 12 week trial was performed on again obese subjects and found that they lost barely any weight but were found to have positive effects on the level of cholesterol.

Yohimbe Extract

Yohimbe (or Yohimbine the chemical found in Yohimbe bark) was investigated for its effects upon body composition and exercise performance in athletes. The subjects were divided into two groups and one ingested a pill containing 20mg of Yohimibine, twice a day for 21 days while the other consumed a placebo. Fat mass was significantly lower in the Yohimibine group compared to the placebo group, although muscle mass or performance had no changes. The researchers concluded that Yohimibine could be used as a fat loss strategy in athletes.

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Mangodrin Side Effects

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Mangodrin is advertised as having no side effects; however this refers purely to African mango seed extract. There are common complaints of unpleasant side effects. These include headaches, trouble sleeping, increased heart rate and vomiting. These are caused by the stimulants in Mangodrin and can affect those with a lower tolerance much worse. Medical advice should be sought before use, particularly if using prescription drugs or if you have a medical condition.

Many customers complained of headaches, particularly when starting the course.
A customer commented saying that they couldn’t sleep at night. The best way to avoid this is not to not take the supplement after 3pm. Some reviews state that the pill gave them a nauseating feeling and one even said “it made me very sick to my stomach and I could not keep it down”. This is so common that many have posted tips for taking the supplement with crackers or wholemeal bread to combat the feeling.

African Mango

This extract is thought to be safe for use for up to 10 weeks. Possible side effects that have been reported in the past include sleep problems, flatulence and headaches.


Caffeine is associated with a number of side effects. These range from mild effects such as headaches, jitteriness and nausea to more severe effects such as dehydration, anxiety, insomnia, increased heart rate and high blood pressure.


Synephrine, or bitter orange, has not been studied in the long-term and so its potential side effects are not yet fully understood. It is thought that the ingredient might cause severe side effects associated with the cardiovascular system; it might cause an increased heart rate and blood pressure and could, in turn, result in stoke or heart attack.

Green Tea

Green tea is not associated with any severe side effects apart from those that have been mentioned above for caffeine. It has been suggested that in the long-term, green tea might cause liver problems, but this potential effect has not been confirmed.

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How to Use

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The official TruDerma website does not contain any information about the supplement itself and does not give usage guidelines. However, these are found on the bottle and it is said to take two pills a day. One capsule is to be taken in the morning with food and 8oz of water and the second is to be consumed in the afternoon with food and water again. Mangodrin comes in a 60 pack supply which is enough to last for a month. There is no information on lifestyle tips for use with Mangodrin however it is advised to exercise and eat sensibly to maximise any effects, as with any supplement.

Although advertised to shed 28 pounds in 10 weeks, GNC (a retailer for Mangodrin) provide an extensive warning with the product that states not to take any longer than 8 weeks. It also says to avoid consuming other caffeine products including tea or coffee.

Pregnant or breastfeeding women should not take Mangodrin due to the stimulating effects. Yohimbe extract, one of the ingredients, has been shown to cause death in infants. These supplements are not suitable for vegetarians as they contain Gelatine. Do not take this supplement if you have a history of cardiovascular problems.

People taking medication should check with their doctor before use, particularly those taking prescription for MAOI inhibitors, antidepressants, aspirin, nonsteroidal anti-inflammatory drugs or products containing phylephrine, ephedrine, pseudoephedrine, or other stimulants.

People with certain medical conditions should also seek medical advice before use. These include heart, liver, kidney, or thyroid disease, psychiatric or epileptic disorders, difficulty urinating, diabetes, high blood pressure, cardiac arrhythmia, recurrent headaches, enlarged prostate or glaucoma.

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Who Makes It?

TruDerma is the company who developed Mangodrin. They were founded in 2011 in Las Vegas and within a year, TruDerma won GNC’s Rising Star Award. The Business Bureau gave TruDerma a rating of A-, on account of having one complaint with regards to their warranty. TruDerma offers a 30-day money-back guarantee, reassuring customers of their confidence. One customer however complained of the difficulty she had in achieving a refund. She stated “I tried to return the product and I was told that it could take a couple of weeks to get used to it, but I never did. I called to ask for a RMA/refund and I was given a telephone number and an email address that nobody ever answered.”

TruDerma state that “Our core values and vision stem from the point of view of our customers” yet the official website does not offer much information with regards to their product. They do not provide ingredient information; this has to be found through third party websites who upload the packaging details. There are also no guidelines for usage and they don’t even explain how the product is supposed to work. They do however, have a forum on their websites and also have twitter and Facebook pages.

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Where to Buy Mangodrin


TruDerma are the manufacturers of Mangodrin and this is their official website. They sell Mangodrin in a pack of 60 capsules, which is a one-month supply, for $50 (around £33). They also sell Mangodrin SF, which is a stimulant free version, for $50. TruDerma also sell a combined pack of Mangodrin and the stimulant free version and recommend using the standard pill during the day and the stimulant free during the evening and this is for sale for $80 (£53).

Their website does not provide much information on the products and does not include ingredients, usage guidelines or any warnings. They have tabs titled “Clinical” and “reviews” but these are blank pages. TruDerma sell 5 other products related to weight management. The company do provide a 30-day money guarantee; however some customers have expressed difficulty when trying to claim back. They offer a free recipe book with every purchase.

GNC is an American retailer for health products. They sell Mangodrin for $43.99 with free US shipping. They provide more information on the product with an image of the label (without ingredient quantities), usage, clinical information and even a large warning. This warning alerts the user to the dangers of the pill when used in conjunction with outside caffeine sources, prescription medicines or medical conditions and is taken from the packaging. The site provides user reviews with an overall rating of 3.5 stars. GNC do not offer the money back guarantee.

Amazon sells Mangodrin for $27.09 (£18). The best thing about Amazon is that they provide images of the product packaging so the buyer can see the ingredients, the usage and the warning before purchase. There are mixed customer reviews on Amazon.

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Does Mangodrin Meet our Approved Criteria

Money-back-guarantee: There is mention of a 30-day money-back guarantee, but customers have complained about the difficulty in getting their money back.

One-off payment: Yes, there does not appear to be an auto-billing scheme.

Manufacturing Standard: No official manufacturing standards are mentioned.

Accompanying Diet Plan: There is no mention of a diet plan.

Ingredients and quantities disclosed: Ingredient quantities are not provided on the official website.

Company contact details readily available: Contact details are not available on the official website – only an online form to fill in.

Mangodrin does not meet our ‘Approved’ criteria as there is no diet plan and some information is lacking, for example, details of manufacturing standards, ingredient quantities and contact details.

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Overall Verdict

The key ingredient in Mangodrin, African mango extract, has been suggested in preliminary trials to have a slight beneficial effect on weight loss. Most of the key ingredients have been studied, but research is generally in very early stages. A number of the ingredients in the product are stimulants and may cause side effects, some of which could be severe. The official website makes several claims that are not backed by any evidence; a full ingredients list and contact details for the company are not provided. The company does offer a money-back guarantee, although customers have complained about the process being challenging.

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One response to “Mangodrin”

  1. leonor says:

    I just started taking Mangodrin today and my mouth is full of Silvia and I think this might be due to the pills… I’m going to stop taking it.

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