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MET-Rx Amino 3000

MET-Rx Amino 3000 seems to pride itself on containing all three branched-chain amino acids, which are essential nutrients needed to build protein in muscles. MET-Rx appears to focus entirely on improving exercise endurance and developing muscle mass, but few other weight loss factors are mentioned in the official product description.

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MET-Rx Amino 3000 Pros
  • Each ingredient appears to work towards very similar goals in the human body, which might make this a more focused and efficient bodybuilding product
MET-Rx Amino 3000 Cons
  • There’s not much research into amino acids’ capabilities in dietary supplements

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MET-Rx Amino 3000 Review

International manufacturer MET-Rx creates this Amino 3000 product, as well as a range of other nutritional supplements. Amino 3000, like many of the creator’s other merchandise, seems targeted at gym-going, bodybuilding consumers. It’s composed entirely of fundamental amino acids that are often most popularly used in supplements to stimulate the building of protein in muscles and allegedly reduce muscle breakdown. Both these attributes should enhance exercise performance and improve muscle tone, although it’s also believed that branched-chain amino acids can combat fatigue for greater endurance. However, the product appears to offer little else to help manage weight and results possibly depend heavily on the exercise regime of the user.

MET-Rx Amino 3000 Claimed weight loss benefits

MET-Rx Amino 3000 seems quite concentrated on which weight loss area it aims to tackle. The presence of all three branched-chain amino acids can reportedly help the product boost the creation of protein in muscles, which can aid body-building during exercise. Some believe that these amino acids fight fatigue and provide the energy to exercise for longer, although this is speculation. However, the official website makes no other claims regarding its product’s body weight or fat loss potential.

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How MET-Rx Amino 3000 Works

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MET-Rx mainly creates supplements based on boosting muscle and bodybuilding, so generally contains elements focused on developing protein in the body. Amino 3000 contains an exceptionally long list of ingredients that are extremely similar in composition and function. Some elements actually produce others, such as l-proline and hydroxyproline, whereas others work to support each other for achieving muscle-enhancement, although it’s difficult to assess the individual contribution of each active ingredient. The similarity of ingredients and brevity of apparent weight loss aims suggest a focus on improving physique rather than boosting weight loss. The FDA hasn’t endorsed any of the product’s claims and its potential remains unproven for safety or success.

L-Glycine
L-glycine, like its fellow ingredients, is a precursor of protein. Muscles are made from two kinds of filaments, actin and myosin, so the body uses amino acids like l-glycine to build more of these two fibres. Glycine can reportedly also regulate sugar levels in the blood and control the rate that glucose is used to make energy, which might work to benefit people suffering from fatigue. Glycine is also an inhibitory neurotransmitter that can influence the central nervous system and sleep quality.

L-Proline
Proline is an amino acid required for producing cartilage and collagen. It assists in breaking down proteins and producing healthy cells, as well as conserving muscle and connective tissues. Proline primarily works to keep muscles and joints agile, which it reportedly does by cushioning joints during movement and helping treat soft tissue strain. Generally, these functions should repair and boost the body for exercising, although the quantity needed to achieve significant effects is unclear.

Hydroxyproline
Hydroxyproline is made from the interaction between proline and ascorbic acid, which is better known as vitamin C. This contact creates an oxygen and hydrogen molecule which then attaches to proline and converts it to hydroxyproline. The most vital structural protein that hydroxyproline makes is collagen, so a deficiency of vitamin C means that collagen cannot be produced. One of the several impacts of this is a breakdown in connective tissue, which could obviously seriously affect physical performance. Another significant creation of hydroxyproline is elastin, which allows the body to handle movement and endure pressure without damage. However, this acid occurs naturally, so consuming extra might be unnecessary.

L-Glutamic Acid
L-glutamic acid is a vital neurotransmitter, similar to l-glycine, that is involved with learning and memory. It works by binding, then activating, cells with glutamate receptors and then stimulates activity in the nervous system. L-glutamic acid also creates glutamine, which works to help stomach function and provide fuel for cells.

L-Alanine
L-alanine is believed to be the most crucial nutrient for amino acid metabolism in blood, alongside l-glutamine. It’s produced from lactic acid by the muscles and is subsequently absorbed through the liver to assist in producing glucose and manage blood sugar levels. This function allows them to provide energy relatively quickly, which could greatly benefit exercise.

L-Arginine
The primary function of l-arginine stems from the moment that the body converts l-arginine into nitric oxide. This causes blood vessels to dilate, which increases and improves the flow of blood. L-arginine also secretes insulin, which regulates blood sugar, as well as assists in many other bodily operations including ridding ammonia and dividing cells. However, its opening of the blood vessels is the function most likely to aid physical performance.

L-Aspartic Acid
Essentially, l-aspartic acid works to build tissue and helps produce other amino acids, such as argininge and lysine, but it also influences the monitoring and release of many hormones. Another function of l-asparic is its ability to convert into the very similar d-aspartic acid, which is known to increase testosterone levels and subsequently boost muscle mass. However, too much of this ingredient might be detrimental to hormonal balance.

L-Serine
Serine is involved in the metabolism of glucose and fatty acids, which could affect energy during exercise, as well as the release of stored glucose in the liver and muscles. Importantly, the body needs serine to create creatine, which is a critical component of enhancing muscle mass. It’s also a predecessor of haemoglobin and so arguably plays a role in the transportation of oxygenated blood cells around the body. However, l-serine has the lowest quantity level of all the named ingredients in this review.

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Key Ingredients

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There’s a huge assortment of ingredients in MET-Rx’s Amino 3000, although all are amino acids. The ones listed in this review are the eight with the highest quantities in the product, which implies that they’ll contribute the most towards weight management and bodybuilding. The employment of branched-chain amino acids in Amino 3000 suggest that this item is reasonably likely to encourage fat loss and advance muscle retention more than many other similar supplements, since it apparently reaches the bloodstream so quickly. However, there have been no follow-up studies on Amino 3000 and so none of its claims can be proven.

L-Glycine
L-glycine is a non-essential amino acid that the body creates naturally if it needs more than is provided in a person’s diet. However, people who want to build muscle mass should consume glycine-rich foods such as: fish, meat and dairy. It’s the smallest of all amino acids in size, but is involved in a plethora of biochemical interactions including: developing DNA strands, forming creatine, producing bile and assisting in the production of transmitters in the brain. Some experts suggest that glycine can be used to interfere with the required blood supply of cancer tumors, as well as act as an aide to treat schizophrenia.

L-Proline
Proline is one of the 20 amino acids that are DNA-coded. However, proline is uniquely structured as a secondary amine and it should strictly be called an imino, not amino, acid. Proline is actually made from a fellow amino acid called l-glutamate and is believed to behave as an agonist of glycine receptors. It is also a osmoprotectant that helps protect tissues from a condition named osmotic stress. This is when vital water movement across a cell membrane dangerously changes, either dehydrating the cell if water is withdrawn, or conversely swelling it to the point of rupture. Proline is even speculated to prevent arteriosclerosis and sustain blood pressure levels.

Hydroxyproline
The non-essential amino acid hydroxyproline is produced from an interaction between proline and vitamin C in the gastrointestinal tract of humans, although it’s also found in plant cells and even some snake poisons. It’s one of the 22 amino acids that play a pivotal part in the body’s protein level and a deficiency of it can cause hair loss, bleeding gums, poor connective tissue and even internal bleeding. This often only occurs through lack of vitamin C rather than proline, as proline is a fellow non-essential amino acid that is made naturally in the body. However, the result of this vitamin deficit triggers the development of the well-known illness scurvy.

L-Glutamic Acid
L-glutamic acid is often confused with glutamine, although it is actually the substance that creates it, and it is one of the most commonly-found molecules in a person’s brain. Glutamic acid is found naturally in humans and animals but it also occurs in eggs, fish, meat and cheese and can be used as a food additive. A company based in China is the world’s largest producer of glutamic acid. Glutamic acid also gets rid of excess nitrogen in the body that is left over after metabolising protein, but overall, l-glutamic is best known for its cognitive benefits and assistance in the nervous system.

L-Alanine
L-alanine might also be referred to as alpha-alanine, as the “l” stands for the “lefthanded” chemical formation of alpha-alanine and “d” stands for the “righthanded” chemical. L-alanine is most commonly used to treat hypoglycemia, due to its ability to produce and control blood sugar when necessary, although it can also be implemented as a treatment for kidney stones due to its skill of neutralising toxins. L-alanine can improve glucose metabolism over long periods, as well as boost muscle mass and enhance physical performance. This strongly supports it as a weight management aide, but it can also motivate the immune system and act as an anti-inflammatory for general wellbeing.

L-Arginine
Arginine occurs naturally and in dairy, fish and meat products, although the human body usually produces all it requires. It might be useful for bodybuilding, but it’s also believed to be a treatment for kidney disease, high blood pressure and coronary heart disease. The body’s supply of arginine becomes low following severe burns of infections, so it is sometimes taken to help recovery. A typical dosage of l-arginine is approximately 2g to 8g each day, which is far higher than the amount in Amino 3000. This adds assurance to its safety value, but casts doubt on its potential as a bodybuilding agent.

L-Aspartic Acid
Aspartic acid, which was discovered in 1827, and glutamic acid are classed as the only two acidic amino acids. Only l-aspartic acid is directly merged into proteins, whereas d-aspartic acid has a far more limited biological part to play. It can also be called asparaginic acid and fundamentally works to assist the creation and discharge of hormones and maintain a healthy nervous system function. The boost in testosterone production it provides is possibly its most useful hormone-related attribute for physical performance. Obviously aspartic acid is made in the human body as it’s a non-essential amino acid, but it is also prevalent in beef, eggs, fish, nuts, beans and lentils.

L-Serine
L-serine is created from sister amino acid glycerine, although plenty of vitamin Bs and folic acid are also required. It is thought to be helpful in providing good physical and mental health, particularly within the brain and central nervous system. L-serine helps with metabolising fat, forming muscle and even adding protection to the sheaths covering nerves that could delay the transmission of messages from brain to nerves. Interestingly it’s needed to make tryptophan, which in turn produces the mood-determining chemical serotonin. Both this, and the suggestion that a deficiency of serine contributes to fatigue, support the theoretical assertion that it can motivate the user into exercising for longer periods.

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Clinical Studies

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Clinical trials are an insightful and invaluable way to evaluate the potential, or actual success, of a weight management product. Preferably, these are conducted before its release on the consumer market, although follow-up studies can still be useful for testing flaws and longevity. Unfortunately, MET-Rx’s Amino 3000 has never been clinically tested, which hinders the ability to accurately assess it. There are many experimental studies into its amino acids individually, but these are very rarely focused on their skill for aiding bodybuilding or weight management. It’s unclear how Amino 3000’s ingredients will work together, but past studies indicate that they usually work relatively well and safely.

L-Glycine
One of l-glycine’s possible benefits for weight training is its skill of regulating blood sugar for sustained energy levels. This study involved nine participants, whose insulin and glucose rates were tested on four different occasions after ingesting various solutions including 4.6g of glycine. Glycine appeared to elevate levels of insulin concentrations throughout the duration of the study, whereas other solutions showed a slight dip in concentration after time. Importantly, glycine showed to trigger the hormone that boosts insulin’s ability to remove glucose from circulation, which is needed for a healthy bloodstream and could benefit the body during physical exertion. This advantage might be slight, but still supports the theory that l-glycine maintains a healthy blood sugar rate.

L-Proline
This clinical trial used chickens to test whether the ingestion method of l-proline affects its capability. The chickens either consumed l-proline extract, l-glutamic acid extract (which produces l-proline) or a diet containing l-proline (corn gluten meal and dried blood meal). The results showed that birds ingesting the l-proline extract had increased signs of l-proline, particularly superior skin strength most probably due to l-proline’s collagen and cartilage production. However, the chickens taking glutamic acid or consuming an l-proline based diet did not show signs of enhanced collagen or improved skin. Unfortunately, this has little bearing on bodybuilding, although it at least shows the potential of l-proline.

Hydroxyproline
This study looked at the impact of taking hydroxyproline for growth, body composition and boosting collagen in tissues. Groups of fish were used as subjects to test this and were subsequently fed a high plant protein diet for ten weeks. The results showed no change in growth performance, but total hydroxyproline and collagen content in the muscles of the fish had significantly grown. This supports the idea that hydroxyproline strongly enhances collagen production, which is vital for maintaining healthy connective tissues and, in turn, physical performance. However, the results of non-human studies are always limited.

L-Glutamic Acid
This clinical trial analysed the enhanced effect extra l-glutamic acid might have on metabolism. Rats were fed a casein diet along with 7.2% glutamic acid and then examined for any biological changes. Findings showed that glutamic acid boosted the level of glutamine in arteries, as well as significantly enhanced the secretion of alanine in the digestive tract and incited the breakdown of glycine and serine, particularly in the muscles. The enhancement of alanine could aid exercise due to its help in energy production, whereas glutamic acid’s effect on glycine and serine show that they can perhaps work well together in Amino 3000. However, glutamine, rather than glutamic acid, appeared superior overall in this test.

L-Alanine
This experiment studied the efficiency and safety of l-alanine after extensive use in humans, which might be useful if using Amino 3000 for long-term results. Experts gave patients suffering from nonalcoholic steatohepatitis (NASH) 6-18g of l-alanine each day for one year and assessed their liver health at the beginning. Only six participants actually completed the trial, but the remaining candidates all showed a gradual improvement of ALT and AST enzymes in their blood. These enzymes are also released into the blood of healthy people, but high levels are observed in patients suffering liver or heart diseases. This implies that l-alanine is relatively safe to consume for at least one year, but some adverse side effects were reported.

L-Arginine
This test looked at whether l-arginine could boost circulation and provide anti-atherosclerosis effects, which means lowering harmful plaque build-up in arteries that hinders the flow of oxgenated blood. Rats and rabbits were given either l-arginine, l-citrulline or a mix of both, followed by serial assessments of the animals’ blood circulations. Results show that the combination solution provided the largest improvements overall, however, l-arginine was superior than l- citrulline at increasing blood flow. L-arginine seemed to enhance nitric oxide production, which is critical for many biological functions including aiding stomach movement for digestion and dilating arteries for exercise. The results aren’t overwhelming, but l- arginine appears to assist in improving blood flow that could help workouts and training.

L-Aspartic Acid
There are very few clinical studies into the workings of l-aspartic acid. However, past research has asserted that it has a strong influence over the secretion of hormones that can possibly affect moods and impulses. The eight men used in this trial were addicted to either: codeine, heroin or opium tincture, but they all ingested dosages of l-aspartic acid to help wean them off their addictions. The final results showed that all the men taking l-aspartic acid were more sociable, communicative and eager to return to everyday life. This suggests that l-aspartic acid has a tangible and positive influence over brain function, although this skill isn’t necessarily transferable to bodybuilders.

L-Serine
This study used chick brains to test how amino acids react to l-serine infusion. Examiners used a solution of different amino acids on the brains and then applied l-serine to test changes. Results showed that the level of taurine decreased, while the concentration of l-alanine rose. This suggests that l-serine can boost the level of l-alanine within Amino 3000, which should assist exercise by helping glucose production and blood sugar regulation. However, taurine is also believed to enhance mental performance, but past animal studies have shown that too much is damaging. Consequently, it might be safer that l-serine appears to reduce it.

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Results

Weight Loss Power: 50/100

MET-Rx’s Amino 3000 doesn’t claim to trigger weight or fat loss. It’s main aims are to assist gym-goers with muscle building and recovery, although arguably if the product motivates the user to exercise more then weight loss is likely to ensue. However, research has shown that many of the amino acids contained in Amino 3000 have blood regulating and digestion-enhancing qualities, which could help prevent sudden drops in sugar levels and allay feelings of hunger.
Speed of results: 60/100

The muscle-building results are likely to be rather rapid, taking into account the amount of research that has analysed the properties of each amino acid. There’s a huge amount of ingredients in Amino 3000 that all appear focused on the same energy producing, glucose regulating and muscle-toning goal. However, the desired outcome will only be brought to fruition through the consumer’s motivation for exercise.
Appetite Suppression: 40/100

The aim of Amino 3000 is to target muscle toning, building and repairing, although the amino acids it uses have many different uses in the human body. However many of these acids, such as l-alanine and l-arginine, work to regulate sugar levels, whereas glutamic acid assists in stomach function. Falling sugar levels triggers a person’s sense of hunger, so if these are regulated for longer this should be avoided. Similarly, controlling digestion could add to this satiety, although the quantity needed for a significant effect is unknown.
Long Term Results: 40/100

Having no follow-up studies to examine and only past client reviews to read limits the evaluation of Amino 3000’s ability on a long-term basis. The ingredient quantity levels per serving might not be enough to cause or sustain a substantial effect and past clinical trials on individual ingredients are generally quite brief. Essentially, it appears that the longevity of Amino 3000’s muscle-boosting benefit will rely on the physical motivation of its consumer.
Safety: 70/100

MET-Rx’s Amino 3000 seems quite safe in comparison to many other caffeine or stimulant based products on the market. It includes amino acids that are all known and produced by humans in modest dosage quantities, which adds significant value to its safety grade. However, the absence of a clinical trial blocks a truly high rating, as it’s unclear how this concoction of amino acids will interact with each other. Reassuringly, other studies into each acid show that dangerous side effects are rare.
Value for money: 65/100

MET-Rx makes no elaborate claims regarding its product’s ability. It’s a muscle building and exercise-enhancing supplement that exploits the proven biological ability of amino acids to achieve its goal. There have also been no damaging complaints or qualms about its safety or success and the manufacturer is an internationally successful company with decades of industry knowledge. However, past examinations into these amino acids were usually carried out using higher quantities than are present in Amino 3000, which suggests that the outcome might be less substantial.

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MET-Rx Amino 3000 Side Effects

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It’s often helpful for the manufacturer to provide a detailed list of all the possible adverse side effects that might occur from using dietary supplements, although this is rarely carried out. Guidelines about who should definitely not take the product are usually given, which is handy, but it’s often down to past research and examinations to evaluate the possible dangers. Reassuringly, Amino 3000 is comprised of a vast range of naturally-occurring human amino acids in quantities that don’t seem likely to trigger negative reactions. However, they appear to have the potential to interfere with specific forms of medication, which should be considered before purchasing.

L-Glycine
L-glycine is believed to be very safe to consume. Studies administering up to 60g of glycerine to subjects showed no adverse side effects and this amount is a great deal more than the 636mg per serving in Amino 3000. However, some experts believe it might have a negative impact on people who’ve recently suffered strokes, although this is not overwhelmingly scientifically supported.

L-Proline
The supposed medical benefit of l-proline for maintaining healthy blood pressure can also work against it. Some experts think proline can incite hypertension (low blood pressure), which is potentially as dangerous as high blood pressure. However, this theory was gleaned from reports of patients already taking medication for hypertension and seemed to be the result of mixing two types of pressure-lowering agents.

Hydroxyproline
There are few studies into the side effects of ingesting too much hydroxyproline, similar to the other ingredients in Amino 3000. This makes it difficult to evaluate its safety, although research into its toxicity suggest it’s a safe substance and the quantity in Amino 3000 isn’t exceptionally high.

L-Glutamic Acid
L-glutamic acid is generally safe to ingest, although too much might cause headaches. However, some research has shown that too much glutamic acid can have a seriously adverse effect on brain function. Calcium ions can enter cells, if excess glutamic acid accumulates. This might cause brain damage and cell death, although this is very rare and there’s no reason to believe that there’s enough in Amino 3000 to incite this outcome.

L-Alanine
L-alanine is created to influence blood sugar levels, which might be detrimental to diabetes sufferers. It might boost sugar in the user’s blood to an unsafe level, so should be used with caution.

L-Arginine
Most research proves l-arginine safe for consumption in levels far higher than that provided by this product, although those on medication should be wary. It might cause some stomach upset and reportedly has the ability to increase stomach acid and interfere with medication, which could harm someone who is suffering a from a gastric ulcer. L-arginine has been reported to influence potassium levels and insulin sensitivity, which might be detrimental to people with liver disease or diabetes respectively. However, the quantity in Amino 3000 is very likely to be too low to cause these effects.

L-Aspartic Acid
It’s generally believed to be unlikely if adhering to recommended doses, but too much l-aspartic acid might raise the level of aspartate and glutamate in the blood that could harm sensitive neurons. Its influence on boosting testosterone should also be treated with caution and those with hormone-related illnesses should probably avoid taking it in a supplement.

L-Serine
It’s often advised that pregnant women not take serine-containing products, but it’s quite safe to consume otherwise. L-serine might trigger feelings of nausea or sleeplessness, however, these are rare and there have been no reports from past users regarding any adverse side effects after taking l-serine.

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How To Use

There’s no information on the official website for Amino 3000 regarding how best to use the product, but its packaging label provides some directions. Amino 3000 is touted as a pre-workout supplement, so the main instruction is to take two or three tablets on an empty stomach prior to exercise. The label also urges users to discuss taking the supplement with a health care official, although seemingly only if using other medication. Pregnant women, nursing mothers and those with a medical condition are not warned off Amino 3000, but advised to speak with their doctor beforehand. However, people under 18 years of age are told not to take it. MET-Rx also points out that the FDA has not assessed Amino 3000 and to stop using the supplement if adverse side effects occur, although it doesn’t indicate what these might be.

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Who Makes MET-Rx Amino 3000

MET-Rx was established by an anaesthesiologist more than 20 years ago in California and claims to research and develop workout aides focusing specifically on protein as an ingredient. The company is possibly best known for its bodybuilding supplements, although its founder created the firm’s original product to prevent seriously ill patients from losing muscle mass. This came in the form of a meal replacement powder, which are currently one of the company’s most popular products. MET Rx has garnered a great deal of hype and publicity over the years and apparently sponsors many athletes and celebrities as well as the World’s Strongest Man competition. It sells a wide selection of merchandise that includes clothing, accessories, protein drinks and daily nutrition, as well as supplements for pre- and post-workouts. However, the firm was involved in the androstenedione dispute during the 1990s, which was a debate in the US regarding the safety and nature of the supplement. The FDA have since banned androstenedione, although it’s not clear how much MET-Rx was involved. There are no money-back guarantee offers, but the firm provides refunds granted the item is returned within 90 days of purchase and there’s no evident reports of customer complaints.

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Where To Buy

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MET Rx appears to have offices and contact centres all over the world and Amino 3000 is available on many American and British websites. The product seems to come in sizes of either: 150 tablets/75 servings, which is more expensive, or 180 caplets/60 servings. It costs $11.99 (£7.73) for one bottle of 180 caplets without shipping fees from Met-Rx.com, although customers can also get it directly from the firm’s many retail stores throughout the US. The UK’s Amazon site sells a 150-size tub for £20.44 with free UK delivery, whereas the Bodybuilding site offers the same size product for £12.15 or 150 tablets for £14.84, both with two-to-three-day shipping. There aren’t any stores to buy Amino 3000 outside of the US, but all these sites have strong credibility and generally deliver good customer and delivery services.

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Overall Verdict

MET-Rx makes it very easy to determine the objective of its Amino 3000 supplement. It’s touted as a muscle-making and exercise-enhancing aide and includes a huge selection of well-researched amino acids that are known to work towards producing and regulating energy naturally within the human body. MET-Rx promises to be a useful component of a keen gym-goer’s exercise regime, as it claims to help create, tone, repair and boost muscle-making for a fit physique. However, it’s unlikely to be appreciated as a general fat-loss aide and requires a customer that will exploit its bodybuilding capability.

Overall: 51/100

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