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Synedrex is advertised as a thermogenic supplement that can accelerate metabolism, eliminate appetite, decrease body fat and leave long lasting results. However, the product has a number of potential side effects, some severe.

Below we have reviewed Synedrex against our review criteria to help consumers make an informed decision.

Synedrex Review

Synedrex Pros
  • Some ingredients have been suggested to aid weight loss in clinical studies
  • Easy to use
Synedrex Cons
  • Very little information about the manufacturer
  • Might cause stimulant-related side effects, some of which could be very severe

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Synedrex Review

Created by the company Metabolic Nutrition, Synedrex is a diet supplement that promises to increase weight loss through an increased metabolic rate and appetite suppression using stimulants as its main ingredients. Not all of the ingredients are backed with clinical studies and most have been associated with side effects. Bitter orange in particular has been suggested to cause adverse cardiovascular events.

Claimed weight loss benefits

The manufacturers of Synedrex, Metabolic Nutrition, claim that the product boosts metabolism, eliminates appetite and decreases body fat. It is therefore said to target three of the five key areas of weight loss.

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How Synedrex Works


The company website claims that Synedrex works in three ways: it activates the metabolic rate to improve caloric burning, maximises energy levels, and uses strong appetite suppressants to suppress your appetite. Synedrex is advertised as a thermogenic supplement. Thermogenics increase the body’s internal temperature, which, in turn, might increase the rate of metabolism, potentially helping you to lose weight quicker.


Methylxanthine, or caffeine, is a stimulant that can provide extra energy and is also said to be able to help to boost metabolism, possibly helping with calorie burning. By providing you with more energy, consumers might be able to exercise for longer which will further increase your calorie burning.

Green Tea Extract

Green tea extract is believed to contain a large amount of antioxidants. It has been suggested to work by boosting your metabolism as well as helping to burn fat. These processes are thought to be improved with the help of certain catechins found in green tea, such as epigallocatechin gallate (EGCG). Evidence in support of the potential weight loss benefits of green tea is however mixed and inconclusive.


Synephrine is the key component of the ingredient bitter orange, which is sometimes added to weight loss products. It has been suggested to increase metabolic rate, which could help the body to burn fat. Also synephrine is considered an appetite suppressant, it supposedly works in this way by sending signals to the brain telling it that you are full.

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Key Synedrex Ingredients

bitter orange peel in t5 fat burner

There are three main ingredients found in Synedrex; these are all believed to work by increasing the metabolism and/or burning fat. Synephrine has also been associated with appetite suppression in the past. All of the ingredients are stimulants and so might cause some related side effects.


Methylxanthide, a form of caffeine, is a stimulant that can provide extra energy as well as purportedly help to boost metabolism and calorie burning. It is said to achieve this by stimulating the nervous system, which supposedly sends signals to the fat cells to tell them to break down – helping to mobilise fats from the fat tissues making it easier to burn.

Green tea extract

Green tea extract is thought to aid weight loss by boosting metabolism and helping to burn fat, principally through the action of its active chemicals known as polyphenols. Green tea extract also contains caffeine and so may act as a stimulant ingredient.


Synephrine, the active chemical in bitter orange, is another stimulant and works in a similar way to methylxanthide, apparently supporting fast metabolic rate. However, it has been suggested that Synephrine has some dangerous effects on the heart, causing cardiovascular reactions that could even result in death.

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Clinical Studies

Clinical Researcher 538

Although the manufacturers of Synedrex claim that their product is approved by physicians due to a number of clinical trials, these trials have only been carried out on individual ingredients and not on the product as a whole. The reaction between ingredients has not been clinically tested.


Extracted from the ingredient bitter orange, synephrine has been advertised as a stimulant beneficial in weight loss. Some studies have found that the ingredient can cause an increase in metabolic rate. Despite this, it has also been found to cause dangerous cardiovascular reactions that overshadow its benefits.

A study published in 2006 reported the effects on the cardiovascular system of a single dose of synephrine; it was found that blood pressure and heart rate were significantly increased in young, healthy adults for up to five hours after taking synephrine when compared to placebo. A paper published by the Canadian Medical Association highlights a number of cases of severe cardiovascular events that could be linked to the consumption of synephrine, particularly when taken alongside caffeine, as is the case in this supplement.

Green Tea Extract

A few trials have been performed to determine the potential effects of green tea on weight loss and weight maintenance. A handy meta-analysis of these studies was published in the International Journal of Obesity in 2009. The authors looked at the results of a selection of studies on green tea extract and body weight, and concluded that the ingredient might have a slight beneficial effect on weight loss and weight maintenance, but that this effect might be variable depending on the user’s ethnicity and caffeine intake.

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Synedrex Side Effects

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There have been many side effects reported from users of Synedrex such as shortness of breath, sweaty palms, nausea and blackouts. The results that come from the clinical trials of its ingredients do not offer much assurance either. Aforementioned studies suggest that Synephrine increases blood pressure and heart rate, and so it might put significant strain on the heart muscle and could cause dangerous cardiovascular reactions.

The manufacturers of Synedrex do warn customers about some of the risks. The Synedrex official website and instruction leaflet warn of risks and side effects such as severe headaches and shortness of breath. However, they do not mention other side effects such as sweaty hands and blackouts, which have been reported by customers.


Caffeine is a stimulant that can provide extra energy, but this extra energy is not always a good thing. It works by raising the heart rate and stimulating the nervous system, causing adrenaline to be released and the subsequent feeling of increased wakefulness. A rapid heartbeat can occur and is one of the most commonly reported from users of Synedrex. Caffeine can also cause nausea, headaches, anxiety, jitteriness, insomnia, and increased blood pressure, amongst other side effects.

Green Tea Extract

Green tea extract is generally thought to be safe for consumption in supplements, although since it contains caffeine, it might cause some of the effects described in the section above. Long-term consumption of large amounts of green tea has been associated with liver problems, although this effect has not yet been proven in scientific studies.


One of the key ingredients in Synedrex is synephrine, which has been found in clinical case studies to cause dangerous cardiovascular reactions. It can cause increases in heart rate and blood pressure, which could result in severe cardiovascular side effects, such as stroke and heart attack.

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How to Use

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The manufacturers of Synedrex are very clear about when to take the pills, and what amount of time to leave between pills. Users are told to take one capsule only when they wake up. If over the first 3 days the effects last longer than 15 hours, they are advised to lower their dosage to one capsule every other day.

The instructions are also clear in their warnings: they point out the excluded groups, such as pregnant and breastfeeding women, and those taking certain medications. They also warn that the user must not take any more than 2 capsules a day or 12 hours before their desired bedtime. Also it isn’t recommended that you continuously use Synedrex for more than 60 days.

Due to the potential cardiovascular side effects associated with synephrine, we would recommend that all potential customers consult a doctor before taking this product. We would not recommend that anybody with a history of cardiovascular problems take Synedrex.

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Who Makes It?

The company behind Synedrex is known as Metabolic Nutrition. Their company website’s ‘About’ page does not offer its customers any background information as to who they are buying the supplements from as it appears to constantly be offline. Their ‘Contact Us’ page does not show any company address or telephone contact number either. It is only when you search their Facebook page that you are offered any information about the company.

The company claims that since 1988, their commitment and dedication to manufacturing high quality nutritional supplements has made it an industry innovator in sports nutrition but does not go into any further detail about its aims or objectives. We are offered a location – Fort Lauderdale in Florida, however it is merely where the company was founded and not where it is based.

As its name suggests, Metabolic Nutrition is a company focused on creating products to boost metabolism and aid in weight loss, yet they do not supply much detail as to where they are located or any other company information.

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Where to Buy Synedrex


Although it is not readily available to buy in UK high street stores, Synedrex can be purchased from the Metabolic Nutrition company website or from other online diet pill retailers. Alternatively, they can be found on eBay and Amazon.

Metabolic Nutrition only offer one option of 45 pills at a price of $59.99 (£38) and orders are usually shipped within 3 – 5 days. This is perhaps the best option as it is guaranteed that you are buying exactly what you want and at £38, this is possibly the lowest price for Synedrex on the market.

Many UK diet pill sellers such as stock Synedrex at competitive prices, with some stockists offering next day delivery. These website sometimes offer discounts and often have sales too. It is important to remember however, to only ever buy supplements from a website you trust.

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Does Synedrex Meet our Approved Criteria

Money-back-guarantee: There is no mention of a money-back guarantee on the official website.

One-off payment: Yes, purchase of the supplement appears to consist of a one-off payment.

Manufacturing Standard: There is no mention of any official manufacturing standards.

Accompanying Diet Plan: A diet plan does not appear to be offered alongside the product.

Ingredients and quantities disclosed: Individual ingredient quantities in the proprietary blend are not provided.

Company contact details readily available: Full contact details are not provided on the official website.

Synedrex does not meet our ‘Approved’ criteria as there is no money-back guarantee or diet plan and some information is lacking from the official website, including manufacturing standards, specific ingredient quantities, and company contact details.

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Overall Verdict

Synedrex is said to boost metabolism and aid in weight loss by acting as an appetite suppressant. However, there is not enough information provided about the manufacturing company to decide whether they are reputable or not and clinical trials have revealed that the product’s key ingredient might be dangerous and can lead to heart failure. The company does not provide much information about itself and contact details are lacking. There is no mention of a money-back guarantee or diet plan.

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One response to “Synedrex”

  1. John Syn says:

    Good review off Synedrex 🙂

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