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XLS Medical Fat Binder Direct

XLS Medical Fat Binder Direct is very similar to the original XLS Medical Fat Binder. XLS Medical Direct comes in powder form – which might make it easier to take, though some customers have complained about the taste.

Below we have reviewed XLS Medical Fat Binder Direct against our review criteria to help consumers make an informed decision.

XLS Medical Fat Binder Direct Pros
  • Some clinical evidence to support main ingredient, Litramine
  • Available from a selection of established retailers
XLS Medical Fat Binder Direct Cons
  • Some information lacking from the official website
  • Clinical evidence for the product as a whole is inconclusive

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XLS Medical Fat Binder Direct Review

One of the big claims made about this product is that it can help users lose up to 3 times more weight than they would do from dieting alone. Studies are referenced by the company that they claim directly relate to their supplement. Omega Pharma also state that because fat-binders tend to remove vital vitamins from the body along with the fat, XLS Medical Fat Binder Direct contains a combination of vitamins A, D and E to improve general health and reduce the risk of side-effects.

Claimed weight loss benefits

Omega Pharma advocate that XLS Medical Fat Binder Direct is able to absorb up to 28% of fat in the diet and remove it from the body. They state that the active ingredient, Litramine, uses a combination of soluble and insoluble fibres which swell up in the stomach and intestines, binding to dietary fat and preventing it from being absorbed into the body. Additionally, Omega Pharma claim that this leads to the user experiencing a feeling of fullness, which helps reduce appetite to stop the consumer eating as much. The Direct element refers to the sachet system the company have introduced to try and make taking the product easier, compared to the traditional tablet form used before.

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How XLS Medical Fat Binder Direct Works


As the company claim, the product contains Litramine, which appears to be the only ingredient aside from vitamins. Litramine is an independent weight loss agent created by InQpharm, another pharmaceutical giant. Litramine is created using the extract of the Opuntia ficus-indica cactus, which is thought to have the ability to retain water. This is why Litramine is thought to be able to help reduce appetite; it supposedly swells up in the gut and creates a ‘full’ feeling. The website describes Litramine’s fat-binding mechanism as being due to two components: insoluble fibres, which bind to the dietary fats in the upper part of the stomach to create large fat-fibre complexes; and soluble fibres, which are able to absorb water to form a thick gel, which stabilises the fat-fibre complex and causes them to pass into the colon, ready for excretion.’s product page reveals that there are additionally fruit extracts and vitamins added to XLS Medical Direct, to help improve the taste and replace lost nutrients respectively. Whilst many customers still complain about the taste, the vitamin content might be beneficial. Each vitamin has a different purpose in the body. Vitamin A is important for helping to protect the immune system, improving vision in poor daylight, and in keeping the skin and linings of the body healthy. Vitamin D helps regulate the levels of calcium and phosphate in the body; both of these micronutrients are needed to maintain bone and tooth health. It’s worth mentioning that the body can also synthesise vitamin D through sunlight touching our skin, so the importance of this micronutrient is debateable. Vitamin E is the least clear in terms of effects, but is believed to help improve cell function by protecting the cell membranes. Unfortunately, Omega Pharma don’t make clear exactly what the concentrations of each of these micronutrients are in their product, and the amount removed in the fat is also unknown, so it’s not entirely clear how important this effect is.

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Key XLS Medical Fat Binder Direct Ingredients

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Litramine is the only known active ingredient in XLS Medical Fat Binder Direct. There are studies provided by Litramine’s manufacturer to support its effectiveness, and also independent studies carried out on products using the same active component, Opuntia ficus-indica extract. The results of the studies are somewhat mixed, with most research suggesting the ingredient might be effective in inducing weight loss, but with others reporting no significant findings.

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Clinical Studies

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The ‘clinical proof’ offered to support XLS’s effectiveness is 4 references to separate papers or articles on the product, the results of which are apparently summarised on XLS’s official website. The results allegedly show that the product can reduce fat absorption by up to 28% with no undesirable side-effects, can reduce cholesterol levels by 10% in 14 days, reduce metabolic syndrome by 39% within 42 days, and can help lose 3x more weight than just customers would through dieting alone; they also claim that 80% of patients reported feeling fuller after taking the product. There is no direct link to any of the studies that allegedly report these findings.

One of the studies used to suggest that metabolic syndrome could be reduced by XLS Medical was actually a test of NeOpuntia, another dieting supplement which uses the leaves of Opuntia ficus-indica (the main active ingredient of XLS); the claimed effects of NeOpuntia on blood lipid levels were examined by a panel of experts on nutrition and dietetics, who actually came to the conclusion that the supplement was not able to significantly alter cholesterol or lipid levels.

However, an actual paper published on this supplement concluded that for 42 women above 45 years of age, there was noticeable decreases in blood lipid levels and a tendency towards decreased triglyceride levels; a quote from the paper states ‘At the study end, 39% of the NeOpuntia group, but only 8% of the placebo group, were no longer diagnosed with metabolic syndrome.’ The NHS define metabolic syndrome as ‘a combination of high blood pressure, obesity and diabetes; decreasing the effects of this syndrome presumably involves weight loss, so the confusion over whether or not NeOpuntia is effective is of great concern. It’s important to note that XLS appear to have manipulated the results of the experiment: they claim that 39% of the syndrome is removed within 42 days, whereas the study actually concludes that 39% of the people involved saw reductions in the syndrome. This could suggest XLS have not checked their sources thoroughly, or that they are being dishonest.

The original XLS Medical Fat Binder provided a study supporting its effectiveness. Omega Pharm summarised the results as demonstrating that XLS could help users lose up to three times more weight than through dieting alone. This study is actually the same study that Litramine provide.


Litramine, the active ingredient in XLS Medical Fat Binder Direct, uses ‘Opuntia ficus-indica’ as the active ingredient, which has been the subject of some studies. The first study examines the effects of Litramine supplementation on roughly half of a group of 125 overweight or obese adults, both male and female, who were given a placebo run for 2 weeks before being given either another placebo or Litramine supplementation in dosages of 3 grams a day. This took place over 12 weeks. The results of the study showed that the mean body-weight change from the average was about 4 (give or take 2) kilograms when taking Litramine, compared to about 1.5 (give or take 2.5) for the placebo. This suggests Litramine is effective in inducing weight loss; however, it’s worth noting that the subjects were encouraged to consume a diet composed of 30% fat on average, which may be higher than dieters would normally consume.

InQpharm also quote results from a study examining the amount of fat present in faecal matter from subjects consuming Litramine. The graph shown on the website shows that after 3 days, the quantity of dietary fat present in the faeces of the subjects taking Litramine was much higher than that present in the placebo group, suggesting more fat was being removed from the body. This study is locatable online, and the results show up to 15.8% more fat excreted with Litramine use than with placebo, as well as greater levels of weight loss. The studies aren’t actually directly linked, and several of the references given are too vague to confirm- one in particular appears to have been planned, but nothing was ever actually carried out. These studies suggest that Litramine could be effective in inducing weight loss- it’s worth mentioning, however, that in the first study the intake of Litramine- 3 grams a day- is probably higher than would be present in a serving of XLS Medical Direct, especially since the Direct version comes in sachets.

A review by the scientists quoted on Litramine’s website, Chong et al, found that Litramine was likely safe at high concentrations. No relevant gastrointestinal effects were noted over a 12 week period, though long term effects cannot be confirmed, and the number of subjects involved is not named here. It’s also worth mentioning that user reviews often mentioned constipation when consuming XLS Medical, which was not mentioned during the litramine study.

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XLS Medical Fat Binder Direct Side Effects

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There are few problems that have been associated with XLS Medical Fat Binder Direct. The active ingredient, Litramine, has been deemed safe through controlled studies of over 100 subjects; one study, led by PW. Chong et al., stated that ‘no significant gastrointestinal effects were observed’ over the duration of the trial. However, there are many customer reviews that state constipation and oily stools as a side-effect, along with occasional claims of bowel cramps. This suggests the potential side-effects of the product may have been played down by the manufacturers; this is supported by the warning given by that ‘taking more than 3 sachets a day could lead to constipation’. Boots also warn that taking large quantities of XLS Medical Fat Binder Direct could lead to ‘mild constipation’, due to the high quantity of fibre it contains.

Litramine supposedly contains a blend of fat-binding fibres that also absorb water, which to some extent obstructs the passage of food through the digestive system. For this reason, certain individuals may wish to avoid this product. Older men and women, who are more likely to become constipated due to weaker digestive systems, might be more likely to experience constipation using this product. People with a particularly low intake of fibre in their diet are also likely to experience issues.

Constipation does not usually cause complications, but it has been linked to haemorrhoids, faecal impaction and bowel incontinence. All of these problems can be avoided by treating the constipation as soon as it becomes apparent. Since the customer is trying to lose weight in the first place, eating fibre-dense foods should be a part of their regime, as fibre is found in most vegetables and fruit, along with fruit juices (though these should be consumed sparingly due to the sugar content). Taking laxatives can also work, though this is an extreme measure, and if the constipation is severe enough to justify buying laxatives, XLS Medical Fat Binder Direct is probably not a suitable product for the customer. Physical exercise should again be a part of every dieter’s regime, and will help loosen stools.

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How to Use

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Omega Pharma give reasonably clear instruction on how to take Fat Binder Direct; they state that ‘no more than 3 sticks (sachets) a day should be consumed’, and that if possible, the product should be taken ‘after meals’. They also recommend that the customer drink at least 2 litres of water a day, for the ‘beneficial action of fibres on gastrointestinal transit’. The additional water is might be beneficial to keep bowel movements regular, to avoid stomach-ache and possible absorption issues. Otherwise, the standard health warnings are given instructing no children, pregnant/breastfeeding women or underweight individuals to take XLS Direct.

Litramine, the active ingredient, is thought to be safe in most situations. A few customers have reported losing disappointingly small amounts of weight on the recommended intake; if customers decide to experiment with increased dosage, they should be careful to never take more than one sachet at any given point in time. This is to avoid an over-concentration of fibre preventing transit through the digestive system, and possibly severe constipation. The safest way to speed up the weight-loss however, is just to eat healthily and exercise regularly; eating vitamin-dense foods will also improve gut health.

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Who Makes It?

The manufacturer of XLS Medical Fat Binder Direct is Omega Pharma, a European pharmaceutical company based in Belgium. They explain themselves to be one of the biggest pharmaceutical companies in Europe, specialising in over the counter medicines, which covers everything from weight loss aids to mosquito repellent; they are associated with some well known brands including ‘Jungle Formula’, ‘Nytol’, ‘TCP’ and health- supplements including Dermalex and Prevalin. In the ‘About’ section of their website, they claim that the central ethos of their company is one of good service to customers and fair treatment of employees, along with thorough training of the pharmacists that they employ. The company was founded in 1987 by Marc Coucke and Yvan Vindevogel, both former ‘Pharmacy’ students at Ghent University.

Both the main website and the pharmacists’ website are well laid out, with an easy to use interface. Omega Pharma give regular news updates on the company’s methodology and values, decisions that have been made and relationships established. If the news they provide is to be believed, they are continually growing; they claim to have a retail sales value of £127 million. XLS medical fat binder is allegedly a £10 million brand, launched two years ago, and is one of the best known fat-binders, sold through large retailers including Boots and Amazon. Their anti-headlice brand is supposedly considered to be the second most popular in the UK.

They provide an address for all customer queries along with a customer service team, telephone number and email address. The company also sponsors a cycling team, Quick Step, which has recently performed very well in most major sporting events and includes big names like Mark Cavendish. In terms of product and company reviews, the company again appears to have fared well. Independent company review website ‘’ estimate the company’s worth at around £5.5 million; they also provide information on the managing staff of the company, suggesting there has been strong correspondence between this website and Omega Pharm, further securing the company’s validity.

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Where to Buy XLS Medical Fat Binder Direct


XLS Medical Fat Binder Direct is sold through multiple retailers, all with slightly different bundle options and delivery costs. Omega Pharma do not retail their product directly, but sell it through a number of well known pharmaceutical companies in the UK, as well as

Amazon retail XLS Medical Fat Binder Direct for £41.65 for a 90 sachet pack; considering the recommended intake of XLS Medical is 3 sticks a day, this is about a month’s supply. This price is supposedly reduced from £70 at the time of writing. Packs of 15 and 30 sachets- a 5 and 10 day supply respectively- are also available. These packs are available for £12.80 and £15 respectively. Subscribing to regular deliveries of this product pushes the price down to £35.40 per purchase for the 90 sachet pack. Amazon also mentions that the product comes with a ‘complimentary 12 week challenge motivational weight-loss program including 1-2-1 support from the XLS-Medical in-house dietician’ (which would need the user to spend at least £136.20). also retail the product, at slightly higher prices than Amazon. The 30 sachet pack- described as a ’10 day trial’- retails at £21.59; the 90 sachet pack retails at £46.66. Again, Boots advertise large price-drops from when the product was initially introduced onto the market. Boots are one of the largest pharmaceutical companies operating in America and the United Kingdom, with branches in most major cities and towns. Their deliveries cost more than Amazon’s, but in this case, they have a slightly wider range of options. For example, customer can choose to pick up a product in-store (and have the product ordered to their local branch) for roughly £2, or can choose to pay almost £3 for standard delivery (4-8 working days); however, since customers will be paying over £45, they should receive their first delivery free.

Lloyds Pharmacy sell XLS Medical Fat Binder Direct in different sized packs to either Boots or Amazon. In addition to the usual 15 and 30 sachet packs, they also sell ‘twin packs’ for 15 and 30 sachets, meaning customers can choose between buying 30 sachets directly or a 15 sachet twin pack for exactly the same quantity. In this case, the 15 sachets twin pack is worse value for money; the 30 twin pack (60 servings) costs £35.00, which is close to the £41.65 Amazon charge for a pack of 90 sachets, making it arguably the inferior purchase. Lloyds Pharmacy is in a similar vein to Boots, being a large pharmaceutical company of reasonable reputation and size. They offer free delivery to their stores, and free home delivery on orders of over £35, which applies to the 30 twin pack, but as mentioned, this is not a sensible purchase.

Similarly, Superdrug, another pharmaceutical company with a more cosmetic focus, retail a 90 sachet pack for £46.66, the same as Boots. They offer free UK delivery on items of over £10, which covers any size pack of XLS Direct purchased from this company, and again offer a free ‘order and collect’ service. They therefore offer a cheaper deal than Boots.

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Does XLS Medical Fat Binder Direct Meet our Approved Criteria

Money-back-guarantee: There is no mention of a money-back guarantee.

One-off payment: Yes, it can be purchased from several well-known retailers.

Manufacturing Standard: There are no manufacturing standards listed.

Accompanying Diet Plan: There is no mention of a diet plan on the official website.

Ingredients and quantities disclosed: A full ingredients list is not provided.

Company contact details readily available: No – only an online form and an email address are provided on the official website.

XLS Medical Fat Binder Direct does not meet our ‘Approved’ criteria as there is no money-back guarantee or diet plan and some information is lacking from the official website, including manufacturing standards, ingredient quantities, and full contact details for the company.

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Overall Verdict

XLS Medical Fat Binder Direct is claimed to target fat binding and appetite suppression with the use of just one key ingredient, obtained from a cactus. Some clinical studies have provided support for the effectiveness of the ingredient, although others have been less positive. Overall, clinical evidence is varied and inconclusive. The product is not likely to cause severe side effects, but customers have complained of gastro-intestinal problems. It is available to purchase from several high street stores in the UK, but there is no money-back guarantee and some important information is not provided on the official product website.

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